Minirin and Its Application
Desmopressin (trade names: DDAVP, DesmoMelt, Stimate,
Minirin) is a synthetic replacement for vasopressin, the hormone that reduces
urine production. It may be taken nasally, intravenously, or as an oral or
sublingual tablet. Physicians prescribe desmopressin most frequently for
treatment of
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| Desmopressin Acetate |
diabetes insipidus, bedwetting, or nocturia
Desmopressin
(1-desamino-8-D-arginine vasopressin)
is a modified form of the normal human hormone arginine
vasopressin, a
peptide containing nine amino acids.Compared to vasopressin, desmopressin's
first amino acid has been deaminated,
and the arginine at
the eighth position is in the dextro rather than the levo form.
Mode of action: Desmopressin
works by limiting the amount of water that is eliminated in the
urine.Desmopressin binds to V2 receptors in renal collecting
ducts,
increasing water reabsorption. It also show its action in release of von Willebrand factor from endothelial
cells by
acting on the V2 receptor.
Desmopressin
is degraded more slowly than recombinant
vasopressin, and requires less frequent administration. In addition, it has
little effect on blood pressure,
while vasopressin may cause arterial hypertension. Vasopressin stimulates the release of ACTH,
which indirectly increases responsiveness of alpha-1 receptor in blood vessel
smooth muscle, increasing vessel tone and blood pressure. Desmopressin does not
stimultate ACTH release, and therefore does not directly raise blood pressure.
Clinical uses:
1.Nocturnal Enuresis: Doctors prescribe desmopressin frequently for treatment. It is usually in the form of desmopressin acetate, DDAVP. Patients taking DDAVP are 4.5 times more likely to sleep without disruption than with placebo. Examples of these situations are overnight camp and sleepovers.US drug regulators banned treating bedwetting with desmopressin nasal sprays after two patients died and 59 other patients suffered seizures. The patients were using desmopressin when they developed hyponatremia, an imbalance of the body's sodium levels.
FDA regulators said
that desmopressin tablets could still be considered safe for nocturnal enuresis treatment, as long as the
patient was otherwise healthy. Patients must stop taking desmopressin if they
become sick and have severe vomiting and diarrhea, fever, the flu, or severe
cold. They should also be very cautious during hot weather or following
strenuous exercise that may make them thirsty.A healthy body needs to maintain
a balance of water and salt (sodium). If sodium levels become too low (hyponatremia)
– either as a result of increased water take-up or reduced salt levels – a
person may have seizures and, in extreme cases, may
die
2. Coagulation disorders: Desmopressin can be used to
promote the release of von
Willebrand factor (with subsequent increase in factor VIII survival secondary to vWF complexing)
in patients with coagulation disorders such as von
Willebrand disease, mild hemophilia A (factor VIII deficiency), and
thrombocytopenia. It can be used with uremic
induced platelet dysfunction. It is not effective in the treatment of
hemophilia B (factor IX deficiency), severe hemophilia A, or von Willebrand 2B.
3.Diabetes insipidus: Desmopressin is used in the treatment of central diabetes insipidus (DI)to replace endogenous ADH that is missing in the central nervous system type of this disorder (decreased production of ADH from the posterior pituitary). It is also used in the diagnostic workup for diabetes insipidus, in order to distinguish central from nephrogenic DI.
In this way the Minirin is used to treat these types of disorder In different amount like minirin 0.1,minirin 0.25 etc
Note : This is Not a Medical Advice , Please Consult your Physician Before Using it . We Will Not be Responsible For any Disorders Caused Due to Using this Drugs
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